Bangalore woman found the world’s first rare blood group, a historical medical discovery marks world news
In a historical medicine success, researchers have discovered an unknown blood group in a 38 -year -old woman from Kolar district, Karnataka. This extraordinary discovery came to light when he was admitted for cardiac surgery and his blood type was found inconsistent with all available O-positive donor units, which was classified as O RH+. The case was extended to the Rotary Bangalore TTK Blood Center and later in the International Blood Group Reference Laboratory (IBGRL) in the UK, identifying a new antigen – Krib. This discovery has global significance, rare blood group leads to research and transfusion therapy.
ORH+ type rare blood mystery shows universal inconsistency before surgery
The patient was initially identified as O Rh+; The most common blood group required a regular transfusion ahead of cardiac surgery. However, none of the standard o positive blood units was compatible. The hospital referred to the case at the advanced immunoematology reference laboratory at Rotary Bangalore TTK Blood Center.“Using the advanced syrupical testing, we found that his blood was ‘paner’s’, which means that it reacts with all available samples. Recognizing the possibility of a rare or unknown blood antigen, we tested 20 family members for compatibility, but there was no match,” from the Rotary Center. Ankit Mathur said. Remarkable, his surgery was successfully completed without transfusion, and his samples were sent to Bristol, UK for further analysis.
Bangalore woman found cradle antigen for the first time
After ten months of research and molecular testing, international experts identified a new antigen in the Crommer (CR) blood group system. In the recognition of its origin, the antigen was officially named cradle – Cromer with “CR” and “IB” for India, Bangalore.Search was publicly declared on 35th Regional Congress of International Society of Blood Transfusion (ISBT) Milan, in Italy, in June 2025. It marks the woman globally as the first person who is confirmed with the Krib Antigen. To support rare or identified blood groups, Rotary Bangalore TTK Blood Center has established a rare donor registry in partnership with Karnataka State Blood Transfusion, IIH (ICMR, Mumbai), and with the support of the International Society of Blood Transfusion.“This discovery confirms India’s contribution to rare blood group research. We have previously supported many rare blood types, with Rh tap and B negative, all documents and internationally presented,” Dr. Mathur said.
Rare blood group success improves future organ transplantation and transfusion security
Rare blood types face serious challenges in emergency infections, organ transplants and complex surgery. Identification of new antigens such as CRIB enhances global transfusion, improves compatibility testing, and gives a foundation for better donor matching better donor in future medical emergency conditions. This success keeps India as a prominent player in global immunoematology research and determines better awareness for rare blood groups worldwide and a platform for advanced donor registries.Also read Who is Audrey Crew? The paralyzed woman has written 20 years later using Elon Musk’s neurlink brain chip
